Journal: Molecular Therapy Oncolytics

Article Title: Upregulated CBX8 Promotes Cancer Metastasis via the WNK2 / MMP2 Pathway

doi: 10.1016/j.omto.2020.09.012

Figure Lengend Snippet: CBX8 Expression Is Upregulated in a Variety of Cancers (A) CBX8 shows higher mRNA-seq expression profile comparing multiple human cancer tissues (in red color) versus normal tissues (in blue) as well as gray (missing TCGA normal sample type). The figure was generated from the COH Bioinformatics Core using Broad Institute TCGA Genome Data Analysis Center (2016): Analysis-ready standardized TCGA data from Broad GDAC Firehose 2016_01_28 run; Broad Institute of MIT and Harvard. Dataset ( https://doi.org/10.7908/C11G0KM9 ). (B and C) Comparison of CBX8 expression in breast cancer, lung cancer, and primary breast to brain metastatic cancer cells via (B) western blotting, and (C) qRT-PCR analysis. ∗p < 0.05. (D) Kaplan-Meier overall survival analysis shows that glioma patients with higher CBX8 expression (n = 131) displayed significantly poorer overall survival than those with lower CBX8 expression (n = 135; p = 1.94e−7) using Glioma Affymetrix microarray cohorts.

Article Snippet: The figure was generated from the COH Bioinformatics Core using Broad Institute TCGA Genome Data Analysis Center (2016): Analysis-ready standardized TCGA data from Broad GDAC Firehose 2016_01_28 run; Broad Institute of MIT and Harvard.

Techniques: Expressing, Generated, Comparison, Western Blot, Quantitative RT-PCR, Microarray